HEREDITARY BREAST CANCER CURRENT STATE OF PROBLEM

Hereditary Breast and Ovarian Cancer – Current Clinical Guidelines in Germany

Zusammenfassung Etwa 5–10% aller Mammaund Ovarialkarzinome sind durch Keimbahnmutationen in bekannten Hochrisikogenen wie BRCA1 oder BRCA2 zurückzuführen. Ein beachtlicher Anteil von Familien mit einer gehäuften Erkrankungsrate weist jedoch keine Mutationen in den bekannten Risikogenen auf. In Deutschland werden seit 2005 die Kosten für genetische Tests und intensivierte Früherkennungsuntersuch...

Hereditary Breast-Ovarian Cancer

Prophylaxis of hereditary breast cancer

Management of Hereditary Breast Cancer

D.M. Eccles, P. Simmonds, J. Goddard, M. Coultas, F. Lalloo, G. Evans and N. Haites in collaboration with the European Familial Breast Cancer Collaborative Group Department of Clinical Genetics, Princess Ann Hospital, Coxford Road, Southampton, UK Medical Oncology, Royal South Hants Hospital, Southampton, UK Medical Statistics and Computing, Southampton General Hospital, Southampton, UK Clinica...

Hereditary breast and ovarian cancer

Familial breast cancer was first recognized in the Roman medical literature of 100 AD [1]. The first documentation of familial clustering of breast cancer in modern times was published by Broca, who reported 10 cases of breast cancer in 4 generations of his wife’s family [2]. In the middle of the nineteen nineties it was proven at the molecular level that a substantial number of breast and ovar...